The Synchronous Neural Interactions test as a functional neuromarker for post-traumatic stress disorder (Posttraumatic Stress Disorder): a robust classification method based on the bootstrap
permalinkJournal of Neural Engineering - 2010-01-20Georgopoulos AP, Tan HRM, Lewis S, Leuthold A, Winskowski AM, Lynch J, Engdahl B10.1088/1741-2560/7/1/016011Traumatic experiences can produce post-traumatic stress disorder (
Posttraumatic Stress Disorder) which is a debilitating condition and for which no biomarker currently exists (Institute of Medicine (US) 2006
PTSD: Diagnosis and Assessment (Washington, DC: National Academies)). Here we show that the
Synchronous Neural Interactionstest which assesses the functional interactions among neural populations derived from magnetoencephalographic (
Magnetoencephalography) recordings (Georgopoulos A P et al 2007 J. Neural Eng. 4 349-55) can successfully differentiate
PTSDpatients from healthy control subjects. Externally cross-validated, bootstrap-based analyses yielded >90% overall accuracy of classification. In addition, all but one of 18 patients who were not receiving medications for their disease were correctly classified. Altogether, these findings document robust differences in brain function between the
PTSDand control groups that can be used for differential diagnosis and which possess the potential for assessing and monitoring disease progression and effects of therapy.