The Number of Cysteine Residues per Mole in Apolipoprotein E Is Associated With the Severity of Posttraumatic Stress Disorder Re-Experiencing Symptoms
permalinkJournal of Neuropsychiatry and Clinical Neurosciences - 2015-03-09Peterson C, James L, Anders S, Engdahl B, Georgopoulos AP10.1176/appi.neuropsych.13090205Apolipoprotien E (
Apolipoprotein E) is involved in critical neural functions and is associated with various neuropsychiatric disorders.
ApoEexists in three isoforms that differ in the number of cysteine residues per mole (CysR/mole). This study evaluated associations between this informative ordinal biochemical scale (CysR/mole) and symptom severity in veterans with
PTSD. Results demonstrated a significant negative relationship between the CysR/mole and severity of
PTSDre-experiencing symptoms, adjusted for trauma. The findings suggest a genetic influence on
PTSDsymptomatology and dovetail with recent advances regarding the molecular mechanisms underlying the differential effects of
ApoEin the brain.