Cortical miscommunication after prenatal exposure to alcohol
permalinkExperimental Brain Research - 2016-11-01Lewis S, Vydrova R, Leuthold A, Georgopoulos AP10.1007/s00221-016-4732-3We report on the effects of prenatal alcohol exposure on resting-state brain activity as measured by
Magnetoencephalography. We studied 37 subjects diagnosed with fetal alcohol spectrum disorder in one of three categories: fetal alcohol syndrome, partial fetal alcohol syndrome, and alcohol-related neurodevelopmental disorder. For each subject, the
MEGsignal was recorded for 60 s during rest while subjects lay supine. Using time series analysis, we calculated the
Synchronous Neural Interactionsfor all pair-wise combinations of 248
MEGsensors resulting in 30,628 partial correlations for each subject. We found significant differences from control subjects in 6.19 % of the partial zero-lag crosscorrelations (
SNI; Georgopoulos et al. in J Neural Eng 4:349-355, 2007), with these differences localized in the right posterior frontal, right parietal, and left parietal/posterior frontal regions. These results show that
MEGcan detect functional brain differences in the individuals affected by prenatal exposure to alcohol. Furthermore, these differences may serve as a biomarker for future studies linking symptoms and signs to specific brain areas. This may lead to new insights into the neuropathology of fetal alcohol spectrum disorders.