A Two-Hit Model of the Biological Origin of Posttraumatic Stress Disorder
permalinkJournal of Mental Health and Clinical Psychology - 2018-10-01Georgopoulos AP, James L, Christova P, Engdahl BWe focus on the origin of
Posttraumatic Stress Disorder, on the meural mechanisms underlying its development. Specifically, we propose a two-hit model for
PTSDdevelopment, with the following components:
- the 1st hit is a neuroimmune challenge, as a preexisting condition
- the 2nd hit is intense glutamatergic neurotrasmission, induced by the traumatic event.
PTSDand maintains associated symptomatology, such as fear and avoidance