Commentary: COVID-19 and the Path to Immunity
permalinkJournal of Immunological Sciences - 2020-11-23James L, Tsilibary EC, Charonis S, Georgopoulos APA recently published Viewpoint1 underscored the importance of T- and B- cell-mediated immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) but omitted to mention the very first step necessary to trigger those responses, namely the formation of a complex between the virus antigen and a suitably matching
Human Leukocyte Antigenmolecule. Here, we discuss the role of
HLAin individual variability in immune response to SARS-CoV-2, emphasizing the implications of
HLAas potentially underlying sustained symptoms seen in "long-COVID", as distinguished from the severe, acute COVID-19, which is associated with "stormy" immune response.