research collageOngoing Studies at the Brain Sciences Center

The primary goal of the research at the Brain Sciences Center is to elucidate the dynamic mechanisms of the working brain in health and disease. The neuroscientists at the Brain Sciences Center are working to unlock the mysteries of debilitating neurological diseases, disorders, and addictions. With today's technology, researchers are able to view these dynamic processes of the working brain, and take the first steps toward understanding the mechanisms which may lead to treatment and prevention to help the millions suffering from brain afflictions.

Gender & Development

Brain areas associated with development and gender differences in healthy subjects.

Objectives: To determine the relations between brain anatomy, brain activity, and neuropsychological measures in healthy females and males, during development and as adults.

Research plan and methods: We plan to study healthy females and males to determine gender differences in brain anatomy and function. Subjects will also be recruited across a broad age range to determine developmental changes in the brain. Subjects will undergo cognitive and motor testing to provide quantitative measures of their behavior. The results of this testing will be related to brain anatomy, as measured by structural MRI, and brain activity, as measured by functional MRI and magnetoencephalography (MEG)/electroencephalography (EEG).


The number of cysteine residues per mole in apolipoprotein E affects systematically synchronous neural interactions in women’s healthy brains

Experimental Brain Research - 2013 Volume 226, Issue 4 - Arthur C. Leuthold, et al

Apolipoprotein E (ApoE) is involved in lipid metabolism in the brain, but its effects on brain function are not understood.

Our results also document the appreciable variation of synchronous neural interaction properties within the various gApoE geontypes, and individuals which points to the existence and important role of other factors involved in shaping brain function at the network level.

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photo of the Brain Sciences Chair logophoto of Brain Sciences ChairThe Brain Sciences Chair

was created by the efforts of a tripartite partnership from private, state and federal sectors including:

American Legion logoThe American Legion Family of Minnesota


U of M logoThe University of Minnesota


VA logoMinneapolis Veterans Affairs Health Care System

This partnership provided funds for an endowed chair in Brain Sciences, as well as office space and general support for the Brain Sciences Center.

Since it opened in 1991, the Center has grown substantially in physical size and personnel. The staff now includes more than 40 people, who come from a variety of academic backgrounds and institutions around the world. All have trained at the Brain Sciences Center on research methods ranging from neurophysiology to brain imaging. This unique blend of people and the integration of many scientific disciplines creates an environment for excellence in research and education.


Updated April 5, 2017