The prefrontal cortex and internally generated motor acts

Current Opinion in Neurobiology - 1992-12-01Goldman-Rakic PS, Bates JF, Chafee M10.1016/0959-4388(92)90141-7
The neuroanatomical and neurophysiological data that have been obtained from experimental primates are converging on a framework for understanding the prefrontal influence on motor output. The framework isolates internally memory-based functions from externally guided sensory-based functions, identifies the internally-based functions with prefrontal circuits, the sensory-based functions with premotor circuits, and integrates the specializations of prefrontal, premotor and subcortical structures in the control of motor acts.