Synchronous Neural Interactions assessed by magnetoencephalography: a functional biomarker for brain disorders
permalinkJournal of Neural Engineering - 2007-08-27Georgopoulos AP, Karageorgiou E, Leuthold A, Lewis S, Lynch J, Alonso A, Aslam Z, Carpenter A, Georgopoulos A, Hemmy LS, Koutlas I, Langheim F, McCarten JR, McPherson SE, Pardo J, Pardo P, Parry GJ, Rottunda SJ, Segal BM, Sponheim S, Stanwyck JJ, Stephane M, Westermeyer JJ10.1088/1741-2560/4/4/001We report on a test to assess the dynamic brain function at high temporal resolution using
Magnetoencephalography. The essence of the test is the measurement of the dynamic
Synchronous Neural Interactions, an essential aspect of the brain function.
MEGsignals were recorded from 248 axial gradiometers while 142 human subjects fixated a spot of light for 45-60 s. After fitting an autoregressive integrative moving average (ARIMA) model and taking the stationary residuals, all pairwise, zero-lag, partial cross-correlations (PCCij0) and their z-transforms (zij0) between i and j sensors were calculated, providing estimates of the strength and sign (positive, negative) of direct synchronous coupling at 1 ms temporal resolution. We found that subsets of zij0 successfully classified individual subjects to their respective groups (multiple sclerosis, Alzheimer's disease, schizophrenia, Sj"ogren's syndrome, chronic alcoholism, facial pain, healthy controls) and gave excellent external cross-validation results.