Scott Sponheim
Former Member of the Brain Sciences CenterBrain Sciences Center (BSC)

Publications

  1. Abnormal cortical neural synchrony during working memory in schizophrenia Clinical Neurophysiology (2018, January) Kang SS, MacDonald III AW, Chafee M, Im CH, Bernat EM, Davenport ND, & Sponheim S
  2. Spatial attentional control is not impaired in schizophrenia: Dissociating specific deficits from generalized impairments Journal of Abnormal Psychology (2015, May) Elshaikh AA, Sponheim S, Chafee M, & MacDonald III AW
  3. Prefrontal neurons transmit signals to parietal neurons that reflect executive control of cognition Nature Neuroscience (2013, September) Crowe D, Goodwin SJ, Blackman R, Sakellaridi S, Sponheim S, MacDonald III AW, & Chafee M
  4. Neuropsychological Testing and Structural Magnetic Resonance ImagingStructural Magnetic Resonance Imaging (sMRI)Performed to assess gray-matter volume. The data are acquired using a Philips 3T Achieva XL magnet with a SENSE 8 channel head coil. Approximately 500,000 voxels per brain are analyzed. In the first analysis, the volume of about 100 separate brain regions is calculated using FreeSurfer software (www.surfer.nmr.mgh.harvard. edu). This provides a coarse-grain, volumetric analysis of areas of the brain. In the second analysis, called voxel-based morphometry, the density of each voxel is assessed for a fine-grain analysis of each area.5 Typically, gray-matter volume decreases with age but at rates that are different for different people, for different areas of the brain, and for men and women. In that sense, one can talk about "gray-matter age" versus chronological age. A person may be 68 years old but have the gray-matter volume of a 50-year-old. Defining brain age based on measurements (as contrasted with chronological age) is a pervasive theme in this project. as Diagnostic Biomarkers Early in the Course of Schizophrenia and Related Psychoses Neuroinformatics (2011, December) Karageorgiou E, Schulz SC, Gollub RL, Andreasen NC, Ho BC, Lauriello J, Calhoun VD, Bockholt, Sponheim S, & Georgopoulos AP
  5. Disrupted functional connectivity for controlled visual processing as a basis for impaired spatial working memory in schizophrenia Neuropsychologia (2011, August) Kang SS, Sponheim S, Chafee M, & MacDonald III AW
  6. Synchronous Neural InteractionsSynchronous Neural Interactions (SNI)Zero-lag partial correlations in pairs of MEG time series and denote the strength and polarity (positive or negative) of neuronal interactions. Anomalies in SNIs as assessed by MEG differentiate psychiatric disorders from healthy brain functioning and can discriminate among various brain diseases. From this research, a highly distinctive, unique PTSD SNI signature characterized by miscommunication of temporal and parietal and/or parieto-occipital right hemispheric areas with other brain areas has emerged. These findings, in addition to the growing research applying MEG to other psychiatric disorders, highlight the utility of MEG in identifying biomarkers of disease and underscore the potential for broader clinical applications of MEG. assessed by magnetoencephalography: a functional biomarker for brain disorders Journal of Neural Engineering (2007, August) Georgopoulos AP, Karageorgiou E, Leuthold A, Lewis S, Lynch J, Alonso A, Aslam Z, Carpenter A, Georgopoulos A, Hemmy LS, Koutlas I, Langheim F, McCarten JR, McPherson SE, Pardo J, Pardo P, Parry GJ, Rottunda SJ, Segal BM, Sponheim S, Stanwyck JJ, Stephane M, & Westermeyer JJ