Scott Lewis, MD PhD
Principal Investigator, Brain Sciences CenterBrain Sciences Center (BSC)
Staff Physician, Neurology Clinic, Minneapolis VA Medical CenterVA Medical Center (VAMC)
Assistant Professor, Department of Neurology, University of Minnesota
Physician, Minneapolis VAMCVA Medical Center (VAMC)
lewis093@umn.edu
Education
PhD, Biochemistry, University of Minnesota
MD, University of Minnesota
BS, Biochemistry, University of Minnesota
Specialty/Focus
functional MRI, Magnetoencephalography Magnetoencephalography (MEG)A noninvasive technique that detects magnetic fields above the surface of the head produced by postsynaptic potentials in the brain., cognitive and motor behavior in health and neurologic disease
Publications
Pages:
1November 2022 through July 2010 •
2July 2010 through April 2002The Synchronous Neural InteractionsSynchronous Neural Interactions (SNI)Zero-lag partial correlations in pairs of MEG time series and denote the strength and polarity (positive or negative) of neuronal interactions. Anomalies in SNIs as assessed by MEG differentiate psychiatric disorders from healthy brain functioning and can discriminate among various brain diseases. From this research, a highly distinctive, unique PTSD SNI signature characterized by miscommunication of temporal and parietal and/or parieto-occipital right hemispheric areas with other brain areas has emerged. These findings, in addition to the growing research applying MEG to other psychiatric disorders, highlight the utility of MEG in identifying biomarkers of disease and underscore the potential for broader clinical applications of MEG. test as a functional neuromarker for Post-traumatic Stress DisorderPost-traumatic Stress Disorder (PTSD)A complex psychiatric syndrome that develops in response to trauma exposure. Individuals with PTSD experience intrusive recollections or reexperiencing of the traumatic event, avoidance of trauma reminders, emotional numbing, and hyperarousal. In addition, PTSD is associated with high rates of concomitant physical and mental health problems, increased health care use, and impairment in social and occupational functioning. Almost 7% of the general population and up to 30% of veterans meet lifetime criteria for PTSD. Indeed, PTSD is one of the most common psychiatric disorders, representing a significant and costly public health concern.: a robust classification method based on the bootstrap Journal of Neural Engineering (2010, January) Georgopoulos AP, Tan HRM, Lewis S, Leuthold A, Winskowski AM, Lynch J, & Engdahl B Cerebral cortical mechanisms of copying geometrical shapes: a multidimensional scaling analysis of Functional Magnetic Resonance ImagingFunctional Magnetic Resonance Imaging (fMRI)A functional neuroimaging procedure using MRI technology that measures brain activity by detecting changes associated with blood flow. This technique relies on the fact that cerebral blood flow and neuronal activation are coupled. When an area of the brain is in use, blood flow to that region also increases.[citation needed] The primary form of fMRI uses the blood-oxygen-level dependent (BOLD) contrast, discovered by Seiji Ogawa. This is a type of specialized brain and body scan used to map neural activity in the brain or spinal cord of humans or other animals by imaging the change in blood flow (hemodynamic response) related to energy use by brain cells. Since the early 1990s, fMRI has come to dominate brain mapping research because it does not require people to undergo shots, surgery, or to ingest substances, or be exposed to ionising radiation, etc. patterns of activation Experimental Brain Research (2009, April) Tzagarakis C, Jerde T, Lewis S, Ugurbil K, & Georgopoulos AP Chronic vagus nerve stimulation for treatment-resistant depression decreases resting ventromedial prefrontal glucose metabolism NeuroImage (2008, August) Pardo J, Sheikh SA, Schwindt GC, Lee JT, Kuskowski MA, Surerus C, Lewis S, Abuzzahab FS, Adson DE, & Rittberg BR P2-027: Association of cognitive deficits with SNISynchronous Neural Interactions (SNI)Zero-lag partial correlations in pairs of MEG time series and denote the strength and polarity (positive or negative) of neuronal interactions. Anomalies in SNIs as assessed by MEG differentiate psychiatric disorders from healthy brain functioning and can discriminate among various brain diseases. From this research, a highly distinctive, unique PTSD SNI signature characterized by miscommunication of temporal and parietal and/or parieto-occipital right hemispheric areas with other brain areas has emerged. These findings, in addition to the growing research applying MEG to other psychiatric disorders, highlight the utility of MEG in identifying biomarkers of disease and underscore the potential for broader clinical applications of MEG. as revealed by magnetoencephalography: A canonical correlation analysis Alzheimer's & Dementia (2008, July) Karageorgiou E, Lewis S, McCarten JR, Leuthold A, Hemmy LS, McPherson SE, Rottunda SJ, & Georgopoulos AP A voxel-by-voxel parametric fMRIFunctional Magnetic Resonance Imaging (fMRI)A functional neuroimaging procedure using MRI technology that measures brain activity by detecting changes associated with blood flow. This technique relies on the fact that cerebral blood flow and neuronal activation are coupled. When an area of the brain is in use, blood flow to that region also increases.[citation needed] The primary form of fMRI uses the blood-oxygen-level dependent (BOLD) contrast, discovered by Seiji Ogawa. This is a type of specialized brain and body scan used to map neural activity in the brain or spinal cord of humans or other animals by imaging the change in blood flow (hemodynamic response) related to energy use by brain cells. Since the early 1990s, fMRI has come to dominate brain mapping research because it does not require people to undergo shots, surgery, or to ingest substances, or be exposed to ionising radiation, etc. study of motor mental rotation: hemispheric specialization and gender differences in neural processing efficiency Experimental Brain Research (2008, July) Christova P, Lewis S, Tagaris GA, Ugurbil K, & Georgopoulos AP Ultra-high field parallel imaging of the superior parietal lobule during mental maze solving Experimental Brain Research (2008, June) Jerde T, Lewis S, Goerke Ute, Gourtzelidis P, Tzagarakis C, Lynch J, Moeller S, Van de Moortele PF, Adriany G, Trangle J, Ugurbil K, & Georgopoulos AP SNISynchronous Neural Interactions (SNI)Zero-lag partial correlations in pairs of MEG time series and denote the strength and polarity (positive or negative) of neuronal interactions. Anomalies in SNIs as assessed by MEG differentiate psychiatric disorders from healthy brain functioning and can discriminate among various brain diseases. From this research, a highly distinctive, unique PTSD SNI signature characterized by miscommunication of temporal and parietal and/or parieto-occipital right hemispheric areas with other brain areas has emerged. These findings, in addition to the growing research applying MEG to other psychiatric disorders, highlight the utility of MEG in identifying biomarkers of disease and underscore the potential for broader clinical applications of MEG. assessed by magnetoencephalography: a functional biomarker for brain disorders Journal of Neural Engineering (2007, August) Georgopoulos AP, Karageorgiou E, Leuthold A, Lewis S, Lynch J, Alonso A, Aslam Z, Carpenter A, Georgopoulos A, Hemmy LS, Koutlas I, Langheim F, McCarten JR, McPherson SE, Pardo J, Pardo P, Parry GJ, Rottunda SJ, Segal BM, Sponheim S, Stanwyck JJ, Stephane M, & Westermeyer JJ Mental maze solving: directional fMRIFunctional Magnetic Resonance Imaging (fMRI)A functional neuroimaging procedure using MRI technology that measures brain activity by detecting changes associated with blood flow. This technique relies on the fact that cerebral blood flow and neuronal activation are coupled. When an area of the brain is in use, blood flow to that region also increases.[citation needed] The primary form of fMRI uses the blood-oxygen-level dependent (BOLD) contrast, discovered by Seiji Ogawa. This is a type of specialized brain and body scan used to map neural activity in the brain or spinal cord of humans or other animals by imaging the change in blood flow (hemodynamic response) related to energy use by brain cells. Since the early 1990s, fMRI has come to dominate brain mapping research because it does not require people to undergo shots, surgery, or to ingest substances, or be exposed to ionising radiation, etc. tuning and population coding in the superior parietal lobule Experimental Brain Research (2005, September) Gourtzelidis P, Tzagarakis C, Lewis S, Crowe D, Auerbach EJ, Jerde T, Ugurbil K, & Georgopoulos AP Logarithmic transformation for high-field BOLD fMRIFunctional Magnetic Resonance Imaging (fMRI)A functional neuroimaging procedure using MRI technology that measures brain activity by detecting changes associated with blood flow. This technique relies on the fact that cerebral blood flow and neuronal activation are coupled. When an area of the brain is in use, blood flow to that region also increases.[citation needed] The primary form of fMRI uses the blood-oxygen-level dependent (BOLD) contrast, discovered by Seiji Ogawa. This is a type of specialized brain and body scan used to map neural activity in the brain or spinal cord of humans or other animals by imaging the change in blood flow (hemodynamic response) related to energy use by brain cells. Since the early 1990s, fMRI has come to dominate brain mapping research because it does not require people to undergo shots, surgery, or to ingest substances, or be exposed to ionising radiation, etc. data Experimental Brain Research (2005, September) Lewis S, Jerde T, Tzagarakis C, Gourtzelidis P, Georgopoulos MA, Tsekos N, Amirikian B, Kim SG, Ugurbil K, & Georgopoulos AP Analysis of fMRIFunctional Magnetic Resonance Imaging (fMRI)A functional neuroimaging procedure using MRI technology that measures brain activity by detecting changes associated with blood flow. This technique relies on the fact that cerebral blood flow and neuronal activation are coupled. When an area of the brain is in use, blood flow to that region also increases.[citation needed] The primary form of fMRI uses the blood-oxygen-level dependent (BOLD) contrast, discovered by Seiji Ogawa. This is a type of specialized brain and body scan used to map neural activity in the brain or spinal cord of humans or other animals by imaging the change in blood flow (hemodynamic response) related to energy use by brain cells. Since the early 1990s, fMRI has come to dominate brain mapping research because it does not require people to undergo shots, surgery, or to ingest substances, or be exposed to ionising radiation, etc. and finger tracking training in subjects with chronic stroke Journal of Neurology (2002, April) Carey JR, Kimberley TJ, Lewis S, Auerbach EJ, Dorsey L, Rundquist P, & Ugurbil K